CB1 Receptor

A cannabinoid receptor found primarily in the brain and central nervous system. CB1 receptors are part of the endocannabinoid system and are the primary target of Delta-9 THC — the binding of THC to CB1 receptors is what produces psychoactive effects. THCA in its raw form does not bind effectively to CB1 receptors, making it non-intoxicating. Caryophyllene is notable for NOT binding CB1 while still producing therapeutic effects through CB2.